Full Title: European Proof-of-Concept Therapeutic Stratification Trial of Molecular Anomalies in Relapsed or Refractory Tumors (ESMART)

Status: Active, Recruiting

Age Range: up to 18 years

Locations: lead centre - Royal Marsden NHS Foundation Trust

Also open in Birmingham, London, Manchester, Newcastle upon Tyne, Sutton

Registry Number: NCT02813135

The trial is available for young patients suffering from relapsed or refractory tumours, including bone sarcomas.

The study involves testing multiple new targeted drugs and chemotherapy treatment combinations that have not previously been available for children and young people. The trial looks at combinations of targeted drugs, immunotherapy and chemotherapy, depending on the mutations (DNA changes) found following the sequencing of the tumour.

This study is a multinational trial recruiting in Denmark, France, Germany, Italy, the Netherlands, Spain and the UK.

The study is supported by CRUK, more information about the trial can be found on their webpage

If you would like any more information on clinical trials in general, please contact us at The Bone Cancer Research Trust. For more information on this trial and to understand if you are eligible, please talk to your clinical team.

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