Completed Research Projects

Could this be the first ever clinical biomarker for chondrosarcoma?

Improving diagnostic methods and treatment planning in chondrosarcoma

Is friendly bacteria the way to target osteosaroma cells?

Using bacteria to deliver treatment directly to the tumour.

Is there an association between fluoride levels in drinking water and bone cancer incidence?

Drinking water and the incidence of bone tumours

PARP: Increasing the effectiveness of radiotherapy and chemotherapy agents

Preventing cancer cells from repairing DNA damage...

Development of a targeted methotrexate prodrug with enhanced therapeutic index for osteosarcoma

Making methotrexate a kinder and more effective treatment for patients.

ICONIC

ICONIC – Improving Outcomes through Collaboration In Osteosarcoma

Validation of DNA methylation-specific markers for circulating tumour DNA analysis in sarcoma patients

Can we develop blood tests to help patients?

Novel tissue engineering technology to facilitate Osteosarcoma Research

Bone-in-culture as an orthotopic platform for the study of patient-near tumour grafts…

Investigating the potential of signalling proteins to monitor and treat adamantinoma relapse and spread

Targeting the MEK5-ERK5 pathway: a novel approach to treat Adamantinoma?

Identification of novel biomarkers for the management of adamantinoma

Novel markers for diagnosis, monitoring and potential treatment of adamantinoma

Novel cell surface protein inhibitors for treatment of Ewing sarcoma

Novel CD99 inhibitors for treatment of Ewing sarcoma

Targeting the Hippo Pathway for Osteosarcoma Therapy

This 'Strictly Research 2017' project looks at the effects of tumour pressure

Improving the science behind personalised medicine

Aiming to predict the effects of therapeutic methods with increased accuracy

A study of bone tumours in children and young adults

Identifying trends in bone tumour incidence..

Can your genetic ‘make-up’ change the way you respond to chemotherapy?

Dr Rachael Windsor studies patients response to chemotherapy drugs...

A pilot-study regarding the cause of osteosarcoma and Ewing sarcoma

Taking steps to investigate the cause of primary bone tumours...

Can bisphosphonates be used in the treatment of osteosarcoma?

Zolendronic Acid and the treatment of osteosarcoma...

Investigating combination treatments in the Ewing Sarcoma Family of Tumours (ESFT)

Investigating a molecule that can halt tumour growth..

A closer look at STAT3 and its behaviour in Ewing sarcoma

A novel approach to treating Ewing Sarcoma..

Creating 3D models to induce tumour cell death

3D models of cells may selectively kill tumour cells..

Can we increase the damage inflicted on cancer cells during chemotherapy and radiotherapy?

Preventing cancer cells from repairing DNA damage...

International Osteosarcoma Research Symposium 2019

Moving osteosarcoma research forward.

A Potential New Therapeutic Target in Osteosarcoma

Investigating ANGPTL4 role in osteosarcoma progression

Evaluating a Diagnostic and Therapeutic Molecule in Ewing sarcoma and Osteosarcoma

Tackling key areas to work towards improving patient response to treatment.

Characterising Osteosarcoma's Microenvironment

Characterising the tumours microenvironment to improve treatment strategies.

Identifying biological treatment targets in osteosarcoma

Screening osteosarcoma cell lines in order to identify therapeutic targets

Determining the function and possible targeting of NG2/CSPG4 in osteosarcoma

Investigating a novel target to prevent the metastasis of osteosarcoma.

Improving patients' quality-of-life and long term outlook

Investigating the function of a regulatory protein in osteosarcoma

The establishment of an osteosarcoma disease model

Developing cell lines to enhance findings and pin-point genetic abnormalities of osteosarcoma

Uncovering FGFR: a complex yet potential treatment target

Can FGFR be targeted to treat ostesarcoma?

Visualising the spread of Ewing sarcoma

Developing tools to study Ewing sarcoma further

Telomerase activity: cell stability, drug resistance and a prognostic factor

Developing techniques to investigates telomerase activity...

Modelling the development of Ewing sarcoma

Visualising the early changes leading to cancer formation...

The perception of clinical trials amongst young people

Determining the reasoning behind low participation in clinical trials...

Searching for the ‘Achilles Heel’ of primary bone cancer

Investigating a novel target to treat bone cancer...

Switching genes back on to treat primary bone cancer

Switching genes back on to treat bone cancer...

The first epigenetic study of chordoma

Investigating genes causing chordoma...

Overcoming Resistance to Chemotherapy in Osteosarcoma

Our 'Strictly Research 2017' winner investigates an obstacle in treating osteosarcoma...

Using Imaging Scans after Chemotherapy to Improve Surgical Planning

Assessing the effectivness of Ewing sarcoma surgical procedures

Putting radiotherapy advances into action for primary bone cancer

Assessing the use of advanced radiotherapy techniques in the treatment of primary bone…

National Ewing Sarcoma Multidisciplinary Team Meeting

Collating data from previous NEMDT meetings to improve the systems and treatment of Ewing…

TP53 restoration using mRNA vaccine technology

TP53 restoration using mRNA vaccine technology

Hypoxic extracellular vesicles in osteosarcoma lung metastasis

Delineating the role of hypoxic extracellular vesicles in pulmonary metastasis of osteosarcoma…

Bone-seeking metal based drugs to treat chemotherapy resistant osteosarcoma

Bone-seeking metal based drugs to overcome chemotherapy resistant osteosarcoma sub-populations

Optimising the treatment of Teenagers and Young Adults with Ewing sarcoma

Optimising the treatment of Teenagers and Young Adults with Ewing sarcoma through an increased…

International collaboration to optimise the management of patients with Ewing sarcoma

International collaboration to optimise the management of patients with Ewing sarcoma

Developing novel biomaterials for osteosarcoma and chordoma treatment

Developing novel biomaterials for osteosarcoma and chordoma treatment

Therapeutic targeting and understanding of oncogenic driver networks in chordoma

Finding targets to develop new treatments for chordoma.

Identification and investigation of a novel gene implicated in treatment resistant Ewing sarcoma

Understanding the Evolutionary Processes of Metastatic Chondrosarcoma

Posthumous evaluation of a high-grade widely disseminated chondrosarcoma through analysis…

A potential new non-invasive biomarker for chordoma

A proof-of-concept study: can cell-free RNA (cfRNA) be used to measure disease burden…

Exploring a new drug target to develop novel combination treatments for Chondrosarcoma

Leveraging a new class of drug target to develop novel combination therapies for Chondrosarcoma

Further exploration of a potential novel therapeutic target in osteosarcoma

Further exploration of ANGPTL4 as a potential therapeutic target in osteosarcoma

Oncolytic virus therapy for Ewing sarcoma

Exploiting the body's own immune system to fight Ewing sarcoma

Unravelling the diversity of bone tumours: investigating the differences between single cancer cells.

Unravelling the diversity of bone tumours

Haem oxygenase-1 (HO-1), a novel druggable target for prevention of osteosarcoma growth and metastasis

By inhibiting HO-1 can we block osteosarcoma development and metastasis?