Completed Research Projects

Is friendly bacteria the way to target osteosaroma cells?

Using bacteria to deliver treatment directly to the tumour.

Is there an association between fluoride levels in drinking water and bone cancer incidence?

Drinking water and the incidence of bone tumours

PARP: Increasing the effectiveness of radiotherapy and chemotherapy agents

Preventing cancer cells from repairing DNA damage...

Development of a targeted methotrexate prodrug with enhanced therapeutic index for osteosarcoma

Making methotrexate a kinder and more effective treatment for patients.

ICONIC

ICONIC – Improving Outcomes through Collaboration In Osteosarcoma

Investigating the potential of signalling proteins to monitor and treat adamantinoma relapse and spread

Targeting the MEK5-ERK5 pathway: a novel approach to treat Adamantinoma?

A pilot-study regarding the cause of osteosarcoma and Ewing sarcoma

Taking steps to investigate the cause of primary bone tumours...

Investigating combination treatments in the Ewing Sarcoma Family of Tumours (ESFT)

Investigating a molecule that can halt tumour growth..

Creating 3D models to induce tumour cell death

3D models of cells may selectively kill tumour cells..

Can we increase the damage inflicted on cancer cells during chemotherapy and radiotherapy?

Preventing cancer cells from repairing DNA damage...

Evaluating a Diagnostic and Therapeutic Molecule in Ewing sarcoma and Osteosarcoma

Tackling key areas to work towards improving patient response to treatment.

Characterising Osteosarcoma's Microenvironment

Characterising the tumours microenvironment to improve treatment strategies.

Improving patients' quality-of-life and long term outlook

Investigating the function of a regulatory protein in osteosarcoma

Visualising the spread of Ewing sarcoma

Developing tools to study Ewing sarcoma further

Telomerase activity: cell stability, drug resistance and a prognostic factor

Developing techniques to investigates telomerase activity...

Modelling the development of Ewing sarcoma

Visualising the early changes leading to cancer formation...

National Ewing Sarcoma Multidisciplinary Team Meeting

Collating data from previous NEMDT meetings to improve the systems and treatment of Ewing…

TP53 restoration using mRNA vaccine technology

TP53 restoration using mRNA vaccine technology

Hypoxic extracellular vesicles in osteosarcoma lung metastasis

Delineating the role of hypoxic extracellular vesicles in pulmonary metastasis of osteosarcoma…

Optimising the treatment of Teenagers and Young Adults with Ewing sarcoma

Optimising the treatment of Teenagers and Young Adults with Ewing sarcoma through an increased…

International collaboration to optimise the management of patients with Ewing sarcoma

International collaboration to optimise the management of patients with Ewing sarcoma

Identification and investigation of a novel gene implicated in treatment resistant Ewing sarcoma

Oncolytic virus therapy for Ewing sarcoma

Exploiting the body's own immune system to fight Ewing sarcoma