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Advancing the ICONIC trial: Improving outcomes through Collaboration in Osteosarcoma
Advancing the ICONIC trial: Improving outcomes through Collaboration in Osteosarcoma
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Exploring a new drug target to develop novel combination treatments for Chondrosarcoma
Leveraging a new class of drug target to develop novel combination therapies for Chondrosarcoma
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In-depth protein analysis to identify tailored treatments for chondrosarcoma patients
A deep dive into the proteomic landscape of chondrosarcoma: improving patient stratification…
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Collecting patient samples for research
Supporting sample collection through Infrastructure Grants
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Supporting rEECur – a clinical trial for recurrent and primary refractory Ewing sarcoma
Biological studies in rEECur, an international randomised controlled trial of chemotherapy…
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Advancing technology for image guided surgery in bone sarcoma
Optimisation of fluorescence technology for bone sarcoma image guided surgery and photodynamic…
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Towards precision medicine in Osteosarcoma
Developing genome-informed treatment to improve outcome in Osteosarcoma
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A potential new non-invasive biomarker for chordoma
A proof-of-concept study: can cell-free RNA (cfRNA) be used to measure disease burden…
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Kinder drugs to treat osteosarcoma
Optimisation of tumour-targeted methotrexate prodrugs for osteosarcoma
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Understanding osteosarcoma chemotherapy resistance
Cellular Dynamics of Chemotherapy Resistance in Osteosarcoma
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Searching for new drugs to treat osteosarcoma
Preclinical validation of novel compounds to treat osteosarcoma
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Developing an effective CAR T cell therapy for osteosarcoma
Towards Engineered T Cells for Osteosarcoma
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Sensitising osteosarcoma to immunotherapy
Modulation of interferon gamma-mediated signalling and immune response by fibroblast growth…
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Developing novel biomaterials for osteosarcoma and chordoma treatment
Developing novel biomaterials for osteosarcoma and chordoma treatment
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Evaluating the therapeutic potential of drugs that destroy dormant chordoma cells
Evaluating the therapeutic potential of senolytic agents in chordoma
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International collaboration to optimise the management of patients with Ewing sarcoma
International collaboration to optimise the management of patients with Ewing sarcoma
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Optimising the treatment of Teenagers and Young Adults with Ewing sarcoma
Optimising the treatment of Teenagers and Young Adults with Ewing sarcoma through an increased…
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TP53 restoration using mRNA vaccine technology
TP53 restoration using mRNA vaccine technology
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Identification of novel biomarkers for the management of adamantinoma
Novel markers for diagnosis, monitoring and potential treatment of adamantinoma
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Investigating the potential of signalling proteins to monitor and treat adamantinoma relapse and spread
Targeting the MEK5-ERK5 pathway: a novel approach to treat Adamantinoma?
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Novel tissue engineering technology to facilitate Osteosarcoma Research
Bone-in-culture as an orthotopic platform for the study of patient-near tumour grafts…
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Haem oxygenase-1 (HO-1), a novel druggable target for prevention of osteosarcoma growth and metastasis
By inhibiting HO-1 can we block osteosarcoma development and metastasis?
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ICONIC
ICONIC – Improving Outcomes through Collaboration In Osteosarcoma
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Development of a targeted methotrexate prodrug with enhanced therapeutic index for osteosarcoma
Making methotrexate a kinder and more effective treatment for patients.
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Sarcoma Awareness for Foundation Doctors
Supporting the awareness of sarcoma, and its care, for junior doctors
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Preventing the Growth and Spread of Osteosarcoma
Investigated a promising treatment target for osteosarcoma spread and growth
Current Research Projects
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