Current Research Projects

Could this be the first ever clinical biomarker for chondrosarcoma?

Improving diagnostic methods and treatment planning in chondrosarcoma

Preventing the Growth and Spread of Osteosarcoma

Investigated a promising treatment target for osteosarcoma spread and growth

Oncolytic virus therapy for Ewing sarcoma

Exploiting the body's own immune system to fight Ewing sarcoma

Sarcoma Awareness for Junior Doctors

Supporting the awareness of sarcoma, and its care, for junior doctors

Collecting patient samples for research

Oxford Sample Collection Infrastructure Grant

Collecting patient samples for research - Birmingham

Birmingham Sample Collection Infrastructure Grant

Development of a targeted methotrexate prodrug with enhanced therapeutic index for osteosarcoma

Making methotrexate a kinder and more effective treatment for patients.

ICONIC

ICONIC – Improving Outcomes through Collaboration In Osteosarcoma

Therapeutic targeting and understanding of oncogenic driver networks in chordoma

Finding targets to develop new treatments for chordoma.

Haem oxygenase-1 (HO-1), a novel druggable target for prevention of osteosarcoma growth and metastasis

By inhibiting HO-1 can we block osteosarcoma development and metastasis?

Validation of DNA methylation-specific markers for circulating tumour DNA analysis in sarcoma patients

Can we develop blood tests to help patients?

Identification and investigation of a novel gene implicated in treatment resistant Ewing sarcoma

Identifying key drivers of chondrosarcoma

Predicting the behaviour of chondrosarcoma

Novel tissue engineering technology to facilitate Osteosarcoma Research

Bone-in-culture as an orthotopic platform for the study of patient-near tumour grafts…

Understanding the Evolutionary Processes of Metastatic Chondrosarcoma

Posthumous evaluation of a high-grade widely disseminated chondrosarcoma though analysis…

Investigating the potential of signalling proteins to monitor and treat adamantinoma relapse and spread

Targeting the MEK5-ERK5 pathway: a novel approach to treat Adamantinoma?

Identification of novel biomarkers for the management of adamantinoma

Novel markers for diagnosis, monitoring and potential treatment of adamantinoma

Novel cell surface protein inhibitors for treatment of Ewing sarcoma

Novel CD99 inhibitors for treatment of Ewing sarcoma

Does oestrogen have a protective effect in chondrosarcoma?

The Role of Oestrogen in Chondrosarcoma Using Patient-Derived Xenograft Models: A Pilot…