Current Research Projects

Demonstrating a novel target for osteosarcoma treatment

Investigating P2X7R in osteosarcoma growth and behaviour

Could this be the first ever clinical biomarker for chondrosarcoma?

Improving diagnostic methods and treatment planning in chondrosarcoma

Preventing the Growth and Spread of Osteosarcoma

Investigated a promising treatment target for osteosarcoma spread and growth

Improving patients' quality-of-life and long term outlook

Investigating the function of a regulatory protein in osteosarcoma

Oncolytic virus therapy for Ewing sarcoma

Exploiting the body's own immune system to fight Ewing sarcoma

Modelling Ewing sarcoma heterogeneity and tumour microenvironment to improve outcomes

Creating a unique preclinical tool combining Ewing sarcoma and tumour microenvironment…

Sarcoma Awareness for Junior Doctors

Supporting the awareness of sarcoma, and its care, for junior doctors

A Potential New Therapeutic Target in Osteosarcoma

Investigating ANGPTL4 role in osteosarcoma progression

Collecting patient samples for research

Oxford Sample Collection Infrastructure Grant

Collecting patient samples for research - Birmingham

Birmingham Sample Collection Infrastructure Grant

Development of a targeted methotrexate prodrug with enhanced therapeutic index for osteosarcoma

Making methotrexate a kinder and more effective treatment for patients.

ICONIC

ICONIC – Improving Outcomes through Collaboration In Osteosarcoma

Therapeutic targeting and understanding of oncogenic driver networks in chordoma

Finding targets to develop new treatments for chordoma.

Haem oxygenase-1 (HO-1), a novel druggable target for prevention of osteosarcoma growth and metastasis

By inhibiting HO-1 can we block osteosarcoma development and metastasis?

Validation of DNA methylation-specific markers for circulating tumour DNA analysis in sarcoma patients

Can we develop blood tests to help patients?

Identification and investigation of a novel gene implicated in treatment resistant Ewing sarcoma

Identifying key drivers of chondrosarcoma

Predicting the behaviour of chondrosarcoma

Evaluating a Diagnostic and Therapeutic Molecule in Ewing sarcoma and Osteosarcoma

Tackling key areas to work towards improving patient response to treatment.