​Since the Bone Cancer Research Trust was formed in 2006, we have awarded over £9.5 million to research focused on improving outcomes for primary bone cancer patients. To date, we have funded 177 research grants and continue to expand our research network, encouraging more researchers to focus their expertise on primary bone cancer.

Open funding calls

Chondrosarcoma Restricted Grant

The Bone Cancer Research Trust is committed to improving outcomes for patients with all types of primary bone cancer and believe the best way to do this is to fund high impact, innovative and collaborative research.

There has been limited progress in the treatment of the commonest bone sarcoma chondrosarcoma, with surgery remaining the mainstay of treatment and no standard of care for systemic treatment. Patients receive life-altering surgeries and are often left with poor functional outcomes, impacting on their quality of life. New targeted, systemic treatments and improved local management are urgent priorities.

To address this, the Bone Cancer Research Trust held a symposium, inviting all interested parties to participate in mapping out progress to date, hurdles and opportunities in chondrosarcoma care and research. The community highlighted the following areas of priority for chondrosarcoma and as such, we particularly welcome applications for funding of up to £500,000 to address one or more of the following, that will lead to a step change in the understanding of the disease or the care of patients.

  • The role of biopsy and issues with accurate grading of chondrosarcoma.
  • The potential of radiomics and imaging data to inform future research.
  • The use of biological material to understand the biology of chondrosarcoma and develop novel treatments.
  • The development of novel models of chondrosarcoma.
  • The development of a national infrastructure to underpin future research and bring together the UK chondrosarcoma community.
  • The quality of life and rehabilitation of chondrosarcoma patients.

We are particularly interested in multi-disciplinary, collaborative proposals, which may be hypothesis driven and generating projects, or projects that build infrastructure to underpin future research.

If an infrastructure building project, proposals must clearly describe the questions and research that this resource will go on to answer and support and an indication of where future applications for further funding may be submitted to support this research. They should include a clear rationale as to why this infrastructure is necessary to deliver improvements for patients and how this may be sustained beyond the scope of this funding.

If a hypothesis driven and generating project, applicants must describe background rationale, including references and preliminary data and must explain how the described experimental design will answer the questions posed in the project and how research may lead to patient benefit.

We are keen to receive proposals combining surgical, translational and biological questions, focused on both improved survival rates and functional outcomes for patients.

Funding is available to researchers and/or clinicians working in an academic or clinical institution in the UK, however, international collaboration is encouraged where appropriate. All costings will be fully scrutinised and so clear justifications should be included.

The Bone Cancer Research Trust is committed to funding research that may lead to patient benefit and ask that all applicants consider the needs of patients when developing their proposal. Applications should demonstrate a clear line of sight to patient benefit, irrespective of how long this may take.

Patient involvement in the development of applications will be expected. The Bone Cancer Research Trust has a Patient and Public Involvement Panel (PPIP), who may be contacted to support your application. Please email us to find out more about how to engage with the panel.

The deadline for applications is 5pm on the 30th September, with awards being made in March 2025.

To request an application form, please contact the Research Team.

Unrestricted Idea Grant 2024

Funding of up to £35,000 is available to support Idea (pilot) grants, focused on any form of primary bone cancer that demonstrate a clear line of sight to patient benefit. We particularly welcome proposals focused on the rarer forms of primary bone cancer and applications using patient samples that are linked to clinical data and outcomes.

This funding is available to researchers and/or clinicians working in an academic or clinical institution in the UK. Applications from younger academics, who do not have a tenured position are encouraged.

We expect applications to be both hypothesis driven and generating. Projects may be discovery focused or translational; regardless of this focus, applicants must demonstrate that they have considered how the project may result in patient benefit or clinical application, irrespectively of timescales.

Key dates

Call opens 1st May 2024

Closing date for applications: 2nd August 2024

Outcomes will be announced in October 2024.

Please contact us here to obtain an application form or for further information.

Collaborative funding for Ewing sarcoma and osteosarcoma

The Bone Cancer Research Trust is excited to be partnering with Children’s Cancer and Leukaemia Group (CCLG) to fund research focused on Ewing sarcoma and osteosarcoma.

Both charities are also delighted to welcome a third collaborator, Ewing's Sarcoma Research Trust (ESRT), whose generous support means that we are able to increase the funding available in this scheme for researchers focusing on Ewing sarcoma specifically.

Over the past several decades, advancements in the treatment of Ewing sarcoma and osteosarcoma have remained limited; both involve intensive and toxic chemotherapy regimens, with patients facing grueling immediate, long term and late effects of treatment, as well as the risk of relapse and recurrence. Methods of determining prognosis and predicting or monitoring response to treatment are also lacking.

All three charities are committed to improving outcomes for patients and believe the best way to do this is to fund high impact, collaborative research.

Ewing sarcoma funding

BCRT, CCLG and ESRT are keen to support both basic science and translational proposals that demonstrate a clear line of sight to patient benefit, irrespective of how far from clinical application the project is. We are particularly interested in applications focusing on the discovery, development or validation of biomarkers of Ewing sarcoma. Biomarkers may be prognostic, predictive or markers of response and may be patient sample derived or imaging biomarkers.

We are also particularly keen to fund research focused on improving the treatment of Ewing sarcoma and patient outcomes – specifically funding improved or new treatment options which are kinder and result in reduced toxicity and less severe long-term side effects.

Funding is available to support Idea grants and Project grants.

Idea or pilot grants should be focused on gaining preliminary data and show a clear path to larger funding applications. These are usually capped at £35,000, however, this may be increased to £50,000 in exceptional cases. Applicants should contact us to discuss this prior to submitting an application.

Funding for Project Grants is usually capped at £250,000, however, we would recommend applicants contact us to discuss proposals seeking funding over this value. These applications must be evidence based and demonstrate a clear trajectory, irrespective of timescales, towards clinical implementation.

Funding is available to both UK and international applicants based in an academic or clinical institution. Please note, international applicants can act as Principal Investigators but must ensure that they include a Co-Applicant or Collaborator based at a UK institution in their application.

Osteosarcoma funding

Funding is available to support Idea (pilot) grants, which should be focused on gaining preliminary data and show a clear path to larger funding applications. These are usually capped at £35,000, however, this may be increased to £50,000 in exceptional cases. Applicants should contact us to discuss this prior to submitting an application. Funding is available to applicants based at a UK academic or clinical institution.

Projects should be hypothesis generating and should be focused on accelerating progress in osteosarcoma research. Projects may be discovery focused or translational, however, must demonstrate thought to patient benefit or clinical application, irrespective of timescales.

Patient & Public Involvement in the development of applications will be expected. The Bone Cancer Research Trust has a Patient and Public Involvement Panel (PPIP), who may be contacted to support your application. Please email us to find out more about how to engage with the panel.

All costings will be fully scrutinised and so clear justifications should be included.

The closing date for this funding scheme is 5pm on Friday 14th June 2024 and awards are likely to be made in Q4 2024.

To request an application, please contact us here.

Improving Sarcoma Diagnosis Funding Call

The Bone Cancer Research Trust and Sarcoma UK are delighted to be working together on this funding call, focussed on research to improve diagnosis for people affected by sarcoma.

Sarcomas are challenging to diagnose. They can affect anyone, occur anywhere in the body, and have over 100 subtypes, with a diverse range of symptoms. But with low case numbers, awareness is poor. These and many other factors contribute to lengthy waits for patients to get the correct sarcoma diagnosis. 1 in 3 sarcoma patients wait at least 6 months from first presenting with symptoms, and it takes bone sarcoma patients an average of 8 visits to a healthcare professional to receive their diagnosis.

In prioritisation exercises carried out by both charities, research into improving diagnosis is a close second priority behind research into new and better treatments for people affected by sarcoma. However, this is a challenging area in terms of developing research proposals which fit the diverse needs of the patient community.

This Improving Sarcoma Diagnosis funding round aims to fund scientific and clinical research projects which ultimately aim to drive positive change in how sarcomas are detected and diagnosed. Proposals must have a clear and considered line of sight towards improving the diagnosis for sarcoma.

The budget for this funding call is £500,000 for research projects applicable to all types of sarcoma or bone sarcoma only. Available grant sizes include:

  • Small grants: innovative pilot projects or requests to support small pieces of follow-on research needed to complete a project up to a maximum value of £100,000.
  • Large grants: substantive pieces of research supporting a member of staff up to a maximum value of £250,000.

Please note that PhD studentships are not offered through this funding calI.

Key dates:

Call opens: February 2024

Deadline for submissions: Applications must be submitted to research@sarcoma.org.uk by 12pm midday (BST) Thursday 20th June 2024. Applications received after this deadline will not be accepted.

Applicant response to peer and lay review: October 2024

Applicants informed of outcome: December 2024

Completed applications should be sent to research@sarcoma.org.uk

For more information on this this funding call, please contact research@sarcoma.org.uk or research@bcrt.org.uk.

Application and guidance forms can be obtained here

Skill development grants

Through this funding scheme, the Bone Cancer research Trust helps UK based primary bone cancer researchers, at all levels in their careers, to travel nationally or internationally, to present their results at internationally recognised research conferences, whilst interacting with other researchers and establishing networks of collaboration.

The funding also enables researchers to travel to international or national laboratories, to carry out a research project or develop a specific skill that can then be applied at their institution of origin.

ELIGIBILITY

All primary bone cancer researchers based at a recognised UK institution. There are no limitations based on career development stage, but applications from early career researchers are particularly encouraged.

WHAT IS FUNDED

Funding for each application is limited to £3000 and should be in line with distance of travel and length of stay.

  • Conference attendance: funding will cover registration, accommodation and travel costs.
  • Laboratory stays: funding will cover travel, accommodation and research expenses to visit a collaborating research group.

This is a rolling scheme; applications may be submitted at any point and will be considered by the Skills Development Grants committee at BCRT.

More details can be found here.

To obtain an application form, please contact us.

Clinical Trials Support Scheme

The Bone Cancer Research Trust are committed to improving outcomes for patients with primary bone cancer and believe the best way to do this is to fund high impact, collaborative research. We are keen to support all stages of research, from pilot projects, through to more substantive research and have developed this funding call to meet these needs.

Funding of up to £100,000 is available to provide additional support ongoing clinical trials. The trial may be observational or interventional and can be oncology or surgical. This additional funding may be used to support:

  • aligned biological studies
  • additional arms or research questions (observational or interventional)
  • toxicology studies

A small proportion of the grant may also be used to support infrastructure costs.

The funding is available for UK applicants and the proposed research or study must take place in the UK; however, the parent clinical trial may be taking place in the UK or internationally.

Proposals should clearly describe the funded trial, including the value of the funding already secured, start date and duration of the funding award and details on data sharing, IP and T&Cs. The proposal should describe the background evidence, including figures and previous publications, that have been used to support the submitted project, how the described design will answer the questions posed in the proposal and how the additional support will give added value to the current trial. The input from patients on the design and development of the proposal should also be described.

Costings submitted will be fully scrutinised and so applicants should fully justify all costs included.

This is a rolling scheme, applications may be submitted at any point and will be considered at the next available meeting of BCRT's Independent Scientific Advisory Panel.

To discuss the scope of this scheme or the possibility of applying for funding over £100,000 and to obtain an application form, please contact us.


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