​Since the Bone Cancer Research Trust was formed in 2006, we have awarded over £5.3 million to research focused on improving outcomes for primary bone cancer patients. To date, we have funded 106 research projects and continue to expand our research network, encouraging more researchers to focus their expertise on primary bone cancer.

Open Grant Calls

Clinical Trials Top-up Scheme

The Bone Cancer Research Trust are committed to improving outcomes for patients with primary bone cancer and believe the best way to do this is to fund high impact, collaborative research. We are keen to support all stages of research, from pilot projects, through to more substantive research and have developed this funding call to meet these needs.

Funding of up to £100,000 is available to provide additional support ongoing clinical trials. The trial may be observational or interventional and can be oncology or surgical. This additional funding may be used to support:

  • aligned biological studies
  • additional arms or research questions (observational or interventional)
  • toxicology studies

A small proportion of the grant may also be used to support infrastructure costs.

The funding is available for UK applicants and the proposed research or study must take place in the UK; however, the parent clinical trial may be taking place in the UK or internationally.

Proposals should clearly describe the funded trial, including the value of the funding already secured, start date and duration of the funding award and details on data sharing, IP and T&Cs. The proposal should describe the background evidence, including figures and previous publications, that have been used to support the submitted project, how the described design will answer the questions posed in the proposal and how the additional support will give added value to the current trial. The input from patients on the design and development of the proposal should also be described.

Costings submitted will be fully scrutinised and so applicants should fully justify all costs included.

This is a rolling scheme, applications may be submitted at any point and will be considered at the next available meeting of BCRT's Independent Scientific Advisory Panel.

To discuss the scope of the this scheme or the possibility of applying for funding over £100,000 and to obtain an application form, please contact us.

The Hamilton Family Programme of Osteosarcoma Research

The Bone Cancer Research Trust are committed to improving outcomes for patients with primary bone cancer. There have been no new treatments approved for osteosarcoma in over 10 years and 5-year survival rates remain low, particularly in metastatic patients.

Over the last few years, a number of key initiatives have commenced that are focused on osteosarcoma, such as ICONIC and more widely in bone sarcoma research, such as the 100,000 Genomes Project and subsequently all patients having access to whole genome sequencing as standard of care.

Despite these initiatives, there has not been an international phase III clinical trial since EURAMOS-1, there are very few early phase trials targeting recruitment of patients with osteosarcoma and few new drugs in development.

The Bone Cancer Research Trust received a generous donation of £1 million to invest in osteosarcoma research. In order to invest this in the most impactful way, the Bone Cancer Research Trust held a planning meeting to discuss the key areas of priority and gaps in osteosarcoma research, which identified the following areas of priority:

  • Pre-clinical models of osteosarcoma
  • Surgical studies
  • Mapping a future clinical trial
  • Predictive biomarkers
  • mTKIs
  • Expansion of ICONIC
  • Immunotherapies and microenvironment
  • Radiomics
  • New drugs
  • Metastasis

The meeting allowed us to map out researchers interested in osteosarcoma research and their interests, which will be available to all interested parties to inform appropriate collaborations.

We are seeking proposals for funding for a programme of osteosarcoma research that are hypothesis driven and with the potential of bringing a step-change in treatment for osteosarcoma. Applications must be from a multi-disciplinary and collaborative team and show a clear line of sight to patient benefit.

Application Process

Stage 1. Expression of Interest

We are seeking expression of interest proposals from lead applicants, including details of the study team, the main area of focus for the research and summary of funding required up to a maximum of £1M. Expression of interests may be focused on one of the key areas of priority identified from the planning meeting or other key areas of osteosarcoma research.

These proposals will be reviewed and the most promising invited to submit a full application.

The deadline for submission of the EOI is 25th March 2022

Stage 2. Full Application

Shortlisted proposals will be awarded up to £1000 to support meetings and PPI to develop the full application.

Proposals should include a robust study design with attention to the planned statistical analyses. Clear plans for the collection, management and sharing of data should be described. Proposals should emphasise and pay particular attention to how the study will benefit patients with osteosarcoma and should describe clearly the vision for progression after this funding. We strongly encourage the submission of proposals that align with relevant ongoing initiatives, describing the benefit of this. Applicants should also describe clearly how they will disseminate the results of their work and how this will act as a catalyst to stimulate further research in osteosarcoma.

Proposals which include a clinical trial are welcomed however, must be within the budget outlined and involvement of a UKCRC registered Clinical Trials Unit is expected.

BCRT encourages applications from younger clinicians and researchers, in partnership with senior colleagues, although the award would be made to a UK institution, strong national/international collaboration is strongly encouraged.

The deadline for full applications is Monday 15th August 2022. The award is likely to be made in Q4 2022.

Open Funding Call

The Bone Cancer Research Trust are committed to improving outcomes for patients with primary bone cancer and believe the best way to do this is to fund high impact, collaborative research.

We are keen to support proposals with a clear line of sight to patient benefit and are particularly interested in applications focusing on the development of new treatments for primary bone cancer and applications focused on early diagnosis, such as biomarker discovery & development, digital pathology, and imaging.

As we currently have funding calls open that are restricted to osteosarcoma, we would particularly welcome applications focused on other forms of primary bone cancer. Research projects on ameloblastoma will not be considered. Epidemiology and quality of life-based projects will not be considered. Available grants are detailed below.

Grant Type

Funding Limit

Eligibility

Ideas

£25,000

Senior post docs may also apply as PI and have salary costs covered.

Open to UK and international applicants

Project

£250,000

Senior post docs may also apply as PI and have salary costs covered.

Open to UK and international applicants, however, any international applicants must have a UK collaborator.

If applicants have any exceptional ideas for projects above these values listed or are unsure if proposals fall within BCRTs research funding remit, we encourage them to contact us at research@bcrt.org.uk for a discussion.

Proposals should be hypothesis driven and clearly describe background evidence (including figures) and previous publications, that have been used to support the submitted project, how the described experimental design will answer the questions posed in the project and how research may lead to patient benefit.

Costings submitted will be fully scrutinised and so applicants should fully justify all costs included.

The closing date for applications will be1st June 2022.

Primary Bone Cancer Consortium Funding Support

The Bone Cancer Research Trust are committed to improving outcomes for patients with primary bone cancer and believe the best way to do this is to fund high impact, collaborative research. We are keen to support all stages of research, from pilot projects, through to more substantive research and the essential infrastructure that underpins this research. We recognise the importance of international collaboration in bone sarcoma clinical and translational research and the need for dedicated time and support to bring people together to facilitate a co-ordinated approach to this research.

We have developed this funding call to support the setting up of or continuation of primary bone cancer consortia that will facilitate both biological and clinical research, with the ultimate aim of improving outcomes for patients. Funding of up to £240,000 is available over a minimum of 3 years is available to support international consortia with a minimum of 5 participating countries.

Proposals should clearly describe the vision and organisational structure of the consortium and any dedicated work packages and should describe both short-term and long term aims.is important that proposals demonstrate how the research may lead to patient benefit and should include patient and public involvement. The Bone Cancer Research Trust has a Patient and Public Involvement Panel, who may be contacted to support your application. Please email us at research@bcrt.org.uk.

This funding is open to applicants based in both UK or international academic institutions, however, applicants from outside the UK will need a UK-based co-applicant and collaborators.

The closing date for applications will be1st July 2022.

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